Leather is one of those guilty pleasures. So if you're going to indulge, do it right. I've been enjoying the latest SENA (http://www.SENAcases.com) for my iPad 2 and they are exceedingly well made. SENA cases are "handcrafted from the finest quality, full-grain genuine leather" and you don't have to take that with a grain of salt... it's true!
SENA offers a plethora of designs, and colors and textures, so you should be able to find one you like. The COLLEGA might be great for the gal heading off to college, or the business woman for that matter, considering the $150 price. It has a hideaway handle so you can grip it like a purse, and the iPad 2 slips right in and closes with a zipper. The interior fabric helps clean the iPad's screen as you insert/remove it. The downside is that there's not much room inside for anything other than the iPad. So SENA has thoughtfully added an external pouch that can hold a few accessories, such as a charger, cable and stylus.
Maybe you want a folio style case, that encloses and protects the iPad while you use it? They offer a variety of such cases, including one with a Bluetooth keyboard! All necessary openings (dock, volume, camera, etc.) are available.
My female colleagues at iPhone Life are always on the lookout for more feminine-friendly accessories, and SENA aims to please. While pricey ($150 typically) they do have cases as low as $60, which isn't much of a premium compared to plastic and 'pleather' cases.